Mutational Signatures - From Methods to Mechanisms

Explore the fascinating world of mutational signatures in this comprehensive tutorial presented by Teresa Przytycka from NCBI at the Computational Genomics Summer Institute (CGSI) 2022. Delve into the journey from methods to mechanisms in understanding mutational signatures, drawing insights from several related research papers. Learn about network-based approaches that elucidate differences within APOBEC and clock-like signatures in breast cancer, techniques for detecting the presence of mutational signatures in cancer with confidence, and the application of Hidden Markov models to create higher resolution maps of mutation signature activity in cancer. Gain valuable knowledge on the latest advancements in computational genomics and their implications for cancer research and biomedical data science.