From Mutagenic Processes to Mutational Signatures and Back

Explore the intricate relationship between mutagenic processes and mutational signatures in this comprehensive lecture by Teresa Prztycka at the Computational Genomics Summer Institute (CGSI) 2023. Delve into cutting-edge research on DNA damage, repair mechanisms, and their contributions to the mutational landscape of cancer. Examine innovative computational approaches, including the RepairSig method for deconvoluting DNA damage and repair contributions, and the DNA repair footprint technique for uncovering the impact of repair mechanisms on mutational signatures. Investigate the influence network model that reveals connections between biological processes and mutational signatures. Learn about network-based approaches that elucidate differences within APOBEC and clock-like signatures in breast cancer. Gain insights from related papers published in prestigious journals such as Cell Systems, Pacific Symposium on Biocomputing, and Genome Medicine, providing a solid foundation for understanding the complex interplay between mutagenic processes and their resulting signatures in cancer genomics.