Evolutionary Models for Cancer and Lineage Tracing - CGSI 2023

Explore evolutionary models for cancer and lineage tracing in this 31-minute conference talk by Ben Raphael at the Computational Genomics Summer Institute (CGSI) 2023. Delve into cutting-edge research on tumor phylogeny inference and CRISPR-Cas9 lineage tracing. Learn about the ConDoR model, which uses a copy-number constrained mutation loss approach for reconstructing tumor evolution. Discover the Startle method, a star homoplasy approach for analyzing CRISPR-Cas9 lineage tracing data. Gain insights into the latest computational techniques for understanding cancer evolution and cellular lineages, drawing from Raphael's recent publications in bioRxiv.