How to Squeeze the Best Genome Assembly From Your HiFi Reads - CGSI 2023

Explore advanced techniques for optimizing genome assembly using HiFi reads in this comprehensive conference talk from the Computational Genomics Summer Institute. Delve into cutting-edge methods for handling segmental duplications, satellites, and allelic variants with high-fidelity long reads. Learn about haplotype-resolved de novo assembly using phased assembly graphs, and discover innovative approaches for assembling complex repetitive regions. Gain insights into the structure, function, and evolution of complete human chromosomes, as well as optical map-based genome scaffolding techniques. Understand how to accurately reconcile genome assemblies using optical maps, and explore the latest advancements in computational genomics for producing high-quality genome assemblies.