Reconstructing Every Haplotype with De Novo Assembly

Explore cutting-edge techniques for reconstructing haplotypes through de novo assembly in this conference talk from the Computational Genomics Summer Institute (CGSI) 2024. Delve into the innovative approaches presented by Haoyu Cheng, focusing on haplotype-resolved assembly methods for diploid and polyploid genomes. Learn about the development and application of tools like hifiasm and double graph, which enable telomere-to-telomere assembly without parental data. Gain insights into the latest advancements in genomic assembly, including phased assembly graphs and scalable techniques for complex genomes. Understand the implications of these methods for improving the accuracy and completeness of genome reconstruction in various species.