Reconstructing Every Haplotype with De Novo Assembly

Explore a 29-minute conference talk from the Computational Genomics Summer Institute (CGSI 2024) focused on groundbreaking approaches to haplotype-resolved de novo genome assembly. Delve into advanced techniques for reconstructing complete haplotypes through assembly methods developed by Haoyu Cheng and colleagues, including the innovative use of phased assembly graphs with hifiasm and double graph technology. Learn about cutting-edge methodologies for assembling diploid genomes without parental data and discover scalable solutions for telomere-to-telomere assembly in both diploid and polyploid genomes. Gain insights from three influential research papers that have significantly advanced the field of genome assembly and haplotype reconstruction.