Rupture Strength of Living Cell Monolayers

Explore the fascinating world of tissue mechanics in this 32-minute conference talk on the rupture strength of living cell monolayers. Delve into the fundamental importance of tissues' ability to withstand mechanical stress and avoid rupture. Discover how rupture can be both undesired in cases of disease or genetic mutations, and an integral part of developmental processes. Gain insights into the multi-scale nature of tissue rupture, involving the interplay between mechanical forces and biological processes at molecular and cellular levels. Learn about the surprising deformation capabilities of epithelial monolayers and their ability to withstand large increases in length before rupture. Understand the role of keratin filaments in controlling tissue stiffness and the impact of perturbing keratin organization. Examine computational approaches that reveal the importance of adhesive bond rupture, tissue rheology, and deformation history in determining tissue strength. Conclude with a comprehensive view of epithelia as versatile materials that balance resistance to shocks with deformability under low strain rates.