Cell Motility in Confluent Tissues Induced by Substrate Disorder

Explore the impact of substrate disorder on cell motility in confluent tissues through this 13-minute talk by Diogo Pinto at the Erwin Schrödinger International Institute for Mathematics and Physics. Delivered as part of the Thematic Programme on "Non-equilibrium Processes in Physics and Biology," discover how the mechanical and chemical properties of underlying biocompatible substrates influence tissue dynamics. Learn about the Self-Propelled Voronoi model's application in understanding the effects of substrate disorder on tissue mechanical properties. Examine findings that reveal increased cell motility and decreased tissue rigidity when disorder occurs at scales smaller than cell size. Compare these results to previous studies on cell mechanical heterogeneity, gaining new insights into tissue dynamics and potential implications for cancer progression.