Bridging Microscopic Cell Dynamics to Nematohydrodynamics of Cell Monolayers

Explore a 26-minute lecture by Aleksandra Ardaseva from the University of Copenhagen on bridging microscopic cell dynamics to nematohydrodynamics of cell monolayers. Delve into a cell-based model of cell layers using phasefield formulation, connecting single-cell mechanical properties to tissue-level nematic and hydrodynamic characteristics. Examine the minimal formulation reproducing bend-splay hydrodynamic instabilities in active matter's continuum nematohydrodynamic formulation, complemented by an analytical description of instability thresholds. Gain insights into the quantitative characterization and comparison of flows and topological defects for extensile and contractile stress generation mechanisms. Discover the emergence of spontaneous gap formation within confluent monolayers resulting from the interplay between cell activity and elasticity. Understand how this research contributes to bridging the gap between micro-scale cell dynamics and tissue-scale collective cellular organization, presented at the Institut Henri Poincaré in Paris.