Towards an Understanding of Chromatin Remodeler Function in Development at Single-Cell Resolution

Explore the role of chromatin regulators in mammalian development and their implications for human developmental disorders in this 52-minute lecture by Dr. David Gorkin, Assistant Professor of Biology at Emory University. Delve into cutting-edge research that utilizes mouse knockout lines to investigate the effects of chromatin regulator loss during development at the molecular level and with single-cell resolution. Gain insights into the developmental cell types and gene regulatory networks that depend on specific chromatin regulators for proper function. Learn about the collaborative efforts between the Gorkin lab, the Jackson Laboratory, and UCSD in this field. Discover the progress made in understanding chromatin remodeler function and consider future opportunities and challenges in this area of study. This lecture is part of the Monthly Seminar on Physical Genomics, a public lecture series sponsored by the Center for Physical Genomics at Northwestern University, the Robert H. Lurie Comprehensive Cancer Center, and NIH Grants.