Center for Physical Genomics and Engineering Courses

Role of Motors in Genome Folding

Explore the physics of chromosome folding, focusing on ATP-consuming motors' role in loop formation and mitotic structures. Learn about analytical models and their implications for genomic organization.

• YouTube
• 48 minutes
• On-Demand
• Free Video

ATP-Dependent Remodeling of Hexasomes, Nucleosomes and Chromatin Condensates

Explore ATP-dependent chromatin remodeling, focusing on INO80's unique hexasome preference and its impact on higher-order chromatin organization. Gain insights into novel mechanisms regulating genome accessibility.

• YouTube
• 58 minutes
• On-Demand
• Free Video

Epigenomic Landscape of Retrotransposon Expression in Senescence and Neurodegeneration

Explore the activation of retrotransposons in aging and neurodegeneration, focusing on LINE-1 elements' role in cellular senescence and potential implications for neurodegenerative diseases.

• YouTube
• 58 minutes
• On-Demand
• Free Video

Many-to-Many Networks: Multifunctional Modules for Multicellularity

Explore how many-to-many protein networks function as versatile computational devices in multicellular organisms and their potential applications in synthetic biology for designing complex behaviors.

• YouTube
• 51 minutes
• On-Demand
• Free Video

Mechanisms and Applications of DNA Methylation and Gene Silencing in Plants

Explore DNA methylation in plants, its role in gene silencing, and CRISPR-based tools for targeted methylation changes in research and crop improvement.

• YouTube
• 46 minutes
• On-Demand
• Free Video

Capturing Biomolecular Interactions at Single-Molecule Level via ABEL Trap Fluorescence Spectroscopy

Explore cutting-edge ABEL Trap fluorescence spectroscopy for observing single-molecule biomolecular interactions, presented by Dr. Allison Squires of the University of Chicago.

• YouTube
• 29 minutes
• On-Demand
• Free Video

Investigating Gene Activation Dynamics in Human Polycomb Chromatin with Synthetic Reader-Effectors

Explore gene activation dynamics in human polycomb chromatin using synthetic reader-effectors. Gain insights from Dr. Karmella Haynes' research on applying chromatin properties to engineer proteins controlling cell development.

• YouTube
• 36 minutes
• On-Demand
• Free Video

Modeling of Nucleosome Clustering in Euchromatin Resulting from Reader Protein Interactions

Explore nucleosome clustering in euchromatin through modeling interactions between reader proteins. Gain insights into chromosomal organization and dynamics from the Spakowitz lab's research.

• YouTube
• 25 minutes
• On-Demand
• Free Video

Ultraresolution Imaging Through Deep Tissue and Information-Based Theoretical Resolution Limit

Explore ultraresolution imaging techniques for deep tissue and discover a novel information-based theoretical resolution limit in this cutting-edge biomedical engineering presentation.

• YouTube
• 31 minutes
• On-Demand
• Free Video

Super-Resolution Imaging of Chromatin Structure and Dynamics in Health and Disease

Explore super-resolution imaging techniques for chromatin structure and dynamics in health and disease with Dr. Melike Lakadamyali's cutting-edge research and insights.

• YouTube
• 32 minutes
• On-Demand
• Free Video

Gene Regulation in Cellular Senescence

Explore gene regulation in cellular senescence with Prof. Masashi Narita, uncovering key insights on epigenetic aspects and senescence-associated heterochromatic foci (SAHFs).

• YouTube
• 35 minutes
• On-Demand
• Free Video

3D Chromatin Rewiring During Melanoma Phenotypic Transition

Explore 3D chromatin architecture's role in melanoma phenotype transitions. Discover how MITF and mechanical factors influence chromatin folding and gene expression in cancer progression.

• YouTube
• 1 hour 2 minutes
• On-Demand
• Free Video

Fossils of Ancient Chromosomes

Explore ancient genome reconstruction using Hi-C technology. Discover how innovative DNA sequencing methods unveil prehistoric chromosomal structures, revolutionizing paleogenomics and evolutionary biology.

• YouTube
• 53 minutes
• On-Demand
• Free Video

The X Factor: Unveiling the Secrets of the X-Chromosome with Data-Driven 3D Modeling

Explore X-chromosome structure and function through data-driven 3D modeling, uncovering insights into sex-specific diseases and potential targeted therapies. Learn about expanding techniques to entire genomes.

• YouTube
• 1 hour 3 minutes
• On-Demand
• Free Video

Towards an Understanding of Chromatin Remodeler Function in Development at Single-Cell Resolution

Explore chromatin regulators' role in mammalian development and human disorders through single-cell analysis of mouse knockouts, uncovering developmental impacts and gene networks.

• YouTube
• 52 minutes
• On-Demand
• Free Video