The X Factor: Unveiling the Secrets of the X-Chromosome with Data-Driven 3D Modeling

Explore the intricate world of X-chromosome structure and function through data-driven 3D modeling techniques in this illuminating lecture by Dr. Anna Lappala from Harvard University. Discover how these advanced modeling methods provide novel insights into X-chromosome organization and its role in health and disease. Examine the differences in chromosomal behavior between normal and compromised states, gaining a deeper understanding of X-chromosome-linked diseases. Learn about variations in gene expression and regulation revealed by this approach, and their potential implications for targeted therapies. Delve into the expansion of these modeling techniques to encompass entire genomes, integrating concepts from graph theory and soft matter physics. Gain valuable insights into the complex interplay among genetic components and their significance for personalized medicine and genetic research. This seminar, part of the Monthly Seminar on Physical Genomics series, offers a comprehensive look at cutting-edge research in chromosome dynamics and its potential impact on understanding sex-specific diseases.