Spermatogenesis - A Paradigm of Stem Cell Regulation

Join Professor Ben Simons from the University of Cambridge for an hour-long seminar exploring the fascinating world of stem cell regulation through the lens of spermatogenesis. Delve into groundbreaking research that challenges traditional views of discrete anatomical niches, examining how stem cells maintain equilibrium between renewal and differentiation in open, facultative environments. Learn about a novel feedback mechanism similar to bacterial quorum sensing, where cells dynamically shift between renewal-biased and differentiation-primed states. Discover how mathematical modeling provides insights into stem cell behavior during steady-state conditions, perturbations, and transplantation scenarios. Explore the broader implications of these findings for understanding epithelial stem cell regulation and interpreting single-cell gene expression data, presented as part of the "New statistical physics in living matter: non equilibrium states under adaptive control" series at the Isaac Newton Institute.