Cis-regulatory Control of Pluripotent Stem Cell Fates

Explore a 55-minute research seminar from Professor Stefan Schoenfelder of the University of Cambridge, focusing on the complex mechanisms of enhancers in gene regulation and pluripotent stem cell development. Delve into cutting-edge methodologies for identifying enhancer target genes genome-wide and discover groundbreaking findings about a novel class of non-canonical enhancers in human induced pluripotent stem cells. Learn how these key gene regulatory elements in the non-coding genome coordinate spatiotemporal gene expression programmes during development, challenging current understanding of enhancer identification based on chromatin signatures. Gain insights into one of genome function's central mysteries - how remote enhancers communicate with their target promoters over large genomic distances. Part of the "New statistical physics in living matter: non equilibrium states under adaptive control" series at the Isaac Newton Institute.