mDBG and Alignment: The Tumultuous Fate of Sequence Bioinformatics Ideas

Explore a comprehensive lecture on sequence bioinformatics ideas, focusing on mDBG (minimizer de Bruijn graphs) and alignment techniques. Delve into the evolution of assembly methods, minimizers, pan-genomics, and equalized genomes. Gain insights into the backstory of mDBG development, including the first prototype and future prospects. Examine the history and benefits of WFA (wavefront alignment) algorithm, discussing its incorporation challenges in mapping tools. Investigate the differences between mapping and alignment, and discover open problems in the field. Learn about various alignment tools and the potential for mapping without alignment.