Osteoporosis 101: Basic Concepts in Osteoporosis Diagnosis & Biphosphonates
Mary Greeley Medical Center via YouTube
Overview
Syllabus
Intro
Objectives
But first, let's review bone turnover
Bisphosphonates- How they work
Change in bone architecture
Alendronate and bone density The FIT trial
Bisphosphonates and osteoporotic fractures
The good...
However... back to bone physiology
Microcracks
Decreased elasticity
Atypical subtrochanteric fractures Definition
Subtrochanteric fractures Epidemiology
Osteonecrosis of the jaw
Do not test too early
The concept of low peak bone mass Bone accrual
Not all T scores are the same...
"Osteopenia" is not a disease-FRAX
Back to case 1
Limit duration of exposure if possible
Can we stop bisphosphonates? FLEX trial
Changes in bone density with drug holiday
Changes in fractures with drug holiday
Who should take a drug holiday?
Back to case 2
Take home points
Taught by
Mary Greeley Medical Center