Osteoporosis 101: Basic Concepts in Osteoporosis Diagnosis & Biphosphonates

Osteoporosis 101: Basic Concepts in Osteoporosis Diagnosis & Biphosphonates

Mary Greeley Medical Center via YouTube Direct link

Intro

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1 of 26

Intro

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Osteoporosis 101: Basic Concepts in Osteoporosis Diagnosis & Biphosphonates

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  1. 1 Intro
  2. 2 Objectives
  3. 3 But first, let's review bone turnover
  4. 4 Bisphosphonates- How they work
  5. 5 Change in bone architecture
  6. 6 Alendronate and bone density The FIT trial
  7. 7 Bisphosphonates and osteoporotic fractures
  8. 8 The good...
  9. 9 However... back to bone physiology
  10. 10 Microcracks
  11. 11 Decreased elasticity
  12. 12 Atypical subtrochanteric fractures Definition
  13. 13 Subtrochanteric fractures Epidemiology
  14. 14 Osteonecrosis of the jaw
  15. 15 Do not test too early
  16. 16 The concept of low peak bone mass Bone accrual
  17. 17 Not all T scores are the same...
  18. 18 "Osteopenia" is not a disease-FRAX
  19. 19 Back to case 1
  20. 20 Limit duration of exposure if possible
  21. 21 Can we stop bisphosphonates? FLEX trial
  22. 22 Changes in bone density with drug holiday
  23. 23 Changes in fractures with drug holiday
  24. 24 Who should take a drug holiday?
  25. 25 Back to case 2
  26. 26 Take home points

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