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Can we stop bisphosphonates? FLEX trial
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Classroom Contents
Osteoporosis 101: Basic Concepts in Osteoporosis Diagnosis & Biphosphonates
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- 1 Intro
- 2 Objectives
- 3 But first, let's review bone turnover
- 4 Bisphosphonates- How they work
- 5 Change in bone architecture
- 6 Alendronate and bone density The FIT trial
- 7 Bisphosphonates and osteoporotic fractures
- 8 The good...
- 9 However... back to bone physiology
- 10 Microcracks
- 11 Decreased elasticity
- 12 Atypical subtrochanteric fractures Definition
- 13 Subtrochanteric fractures Epidemiology
- 14 Osteonecrosis of the jaw
- 15 Do not test too early
- 16 The concept of low peak bone mass Bone accrual
- 17 Not all T scores are the same...
- 18 "Osteopenia" is not a disease-FRAX
- 19 Back to case 1
- 20 Limit duration of exposure if possible
- 21 Can we stop bisphosphonates? FLEX trial
- 22 Changes in bone density with drug holiday
- 23 Changes in fractures with drug holiday
- 24 Who should take a drug holiday?
- 25 Back to case 2
- 26 Take home points
