COURSE OUTLINE: In the biosphere, the chemistry must be considered in the context of the cell, or an organ, or even a whole organism. That makes mimicking of biological processes to be extremely challenging as the reaction needs to be performed with perfect orthogonality to other functional entities present in a biological system. Today, with the advancement of various spectroscopic and molecular biology techniques and with a better understanding of chemical principles, functions of various bio molecules have been unravelled which has paved the way for development of newer drugs. The present course is an attempt to bridge the gap in our understanding of biological systems and processes at the molecular and functional level. The course first introduces the various kinds of bio molecules, macro to medium size to small, their structures and functions followed by molecular engineering to manipulate their activity and biosynthesis. That creates a perfect platform for the next module on drug design and discovery.
Organic Chemistry in Biology and Drug Development
NPTEL and Indian Institute of Technology, Kharagpur via YouTube
Overview
Syllabus
Organic Chemistry in Biology and Drug Development.
Lecture 1 : A brief introduction to Molecules of Life.
Lecture 2 : Biological Macro molecules and Small molecules: Importance and functions.
Lecture 3 : Amino Acids: The building block of proteins.
Lecture 4 : Amino acids: separation and detection, Electrophoresis and Ninhydrin reaction.
Lecture 5 : Method of determination of Amino acid sequence: primary structure of polypeptide/protein.
Lecture 6 : Selective peptide bond cleavage: Enzymatic and Non-enzymatic methods.
Lecture 7 : Peptide synthesis: Protecting groups for amine and carboxyl functionality.
Lecture 8 : Peptide synthesis (continued): Protection, coupling and deprotection methods.
Lecture 9 : Recent development of coupling agents;.
Lecture 10 : Hierarchial structure of proteins: Secondary, tertiary and quaternary structure.
Lecture 11 : Ramachandran plot and protein purification techniques.
Lecture 12 : Protein Purification Techniques (Contd.).
Lecture 13 : Introduction to Enzymes and its kinetics.
Lecture 14 : Enzyme catalysed reactions and introduction to catalytic activity of proteases.
Lecture 15 : Enzyme Kinetics (Contd.).
Lecture 16 : Concept of Enzyme Inhibition.
Lecture 17 : Concept of Enzyme Inhibition (Contd.).
Lecture 18 : Problems on Enzyme Kinetics and Enzyme Inhibition.
Lecture 19 : Synthetic Biology.
Lecture 20 : Synthetic Biology (Contd.).
Lecture 21 : Synthetic Biology (Contd.).
Lecture 22 : Nucleic Acid.
Lecture 23 : Nucleic Acid (Contd.).
Lecture 24 : DNA sequencing method.
Lecture 25 : DNA sequencing method (Contd.).
Lecture 26 : DNA sequencing method (Contd.).
Lecture 27 : Synthesis of oligonucleotide.
Lecture 28 : Central dogma: DNA replication, transcription and translation.
Lecture 29 : Central dogma: DNA replication, transcription and translation (Contd.).
Lecture 30 : Central dogma: DNA replication, transcription and translation (Contd.).
Lecture 31 : Central dogma: DNA replication, transcription and translation ((Contd.).
Lecture 32 : Central dogma: DNA replication, transcription and translation (Contd.).
Lecture 33 : Molecular Biology.
Lecture 34 : Molecular Biology (Contd.).
Lecture 35 : Chemistry of cofactors/coenzymes.
Lecture 36 : Chemistry of cofactors/coenzymes (Contd.).
Lecture 37 : Chemistry of cofactors/coenzymes (Contd.).
Lecture 38 : Chemistry of cofactors/coenzymes (Contd.).
Lecture 39 : Chemistry of cofactors/coenzymes (Contd.).
Lecture 40 : Chemistry of cofactors/coenzymes (Contd.).
Lecture-41: " Introduction to Drug Discovery Process".
Lecture-42: " Fundamental Principles of Drug Development Process".
Lecture-43: " Combinatorial chemistry".
Lecture-44: "Neurotransmitters".
Lecture-45: " Catechol amine based and GABA neurotransmitters".
Lecture-46: " Hypertension: humoral mechanism and renin/angiotensin system".
Lecture-47: " Inhibitor design of angiotensin converting enzyme".
Lecture 48: Antimicrobial drugs.
Lecture 49: Chemistry of penicillins.
Lecture 50: Resistance to beta-lactam antibiotics.
Lecture 51: Mechanistic studies of beta-lactamase.
Lecture 52: Non beta-lactam antibiotics.
Lecture 53: Mechanistic enzymology of Isopenicillin N synthase.
Lecture-54 : Polyketide Biosynthesis.
Lecture 55 : Biosynthesis of macrolide polyketides and introduction to virus.
Lecture 56 : Anti-viral drugs.
Lecture-57 : Cancer and Chemotherapy.
Lecture-58 : Anti-cancer drugs (contd).
Lecture 59 : Aromatase inhibition and Anti-ulcer drugs.
Lecture-60 : Cholesterol lowering agents.
Lecture 61 : Cholesterol Biosynthesis.
Lecture-62 : Pharmakinetics and pharmadynamics.
Lecture-63 : QSAR principles.
Taught by
IIT Kharagpur July 2018
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Reviews
4.5 rating, based on 34 Class Central reviews
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This course on "Organic Chemistry in Biology and Drug Development" offers a comprehensive exploration of the vital role organic chemistry plays in understanding biological processes and developing life-saving medications. With engaging lectures and practical applications, it effectively bridges the gap between organic chemistry principles and their real-world applications in drug discovery. The course equips students with valuable knowledge and skills essential for pursuing careers in pharmaceuticals, biotechnology, and related fields. Overall, it's a highly recommended course for anyone interested in the intersection of organic chemistry, biology, and drug development.
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The course is great especially for students trying to get into medicinal/pharmaceutical chemistry. It is easy to understand and digest. The lessons are simplifed so people with basic knowledge of chemistry can easily assimilate. It is also relevant and understandable. Concepts are simplifed for clarity. A class worth taking
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good course, understood everything taught in depth. highly recommended. I was specifically looking for this course and was happy to learn from it
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Priyanuj ParasarAs an avid learner in the realm of biology and drug development, I recently embarked on a journey through the online course "Organic Chemistry in Biology and Drug Development." This course promised to unravel the intricate connections between organi… -
This course was an excellent exploration of the intersection between organic chemistry, biology, and drug development. It masterfully blended foundational organic chemistry concepts with their real-world applications in biological systems and pharmaceutical research. The instructors did a great job of explaining complex topics like enzyme mechanisms, molecular interactions, and drug design, making them accessible even for students without a strong chemistry background.
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Muhammad ImranIt was great. It was beneficial. I got some basic and fundamental knowledge from this course, and i am hopeful that this course will definitely help me in research work. It was well arranged, and giving every information about biochemistry and drugs development as well. -
This course is very helpful for know about drugs Also how to develop the drugs . Faculty is very Nice person . He easily interpretation of the topic therefore we can easily understand.From this course I made note because in future I can use it and it helpful for me
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Thank you so much for an amazing course! I learned so much and you made even the more complex topics interesting and easier to follow through real-world stories and case studies.” “The course and all the materials are both comprehensive and informative.
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Good to understand and Easy to learn
Easy , Some topic is Very Easy like DNA and Amino acid and biochemistry Over all good to under stand -
Very helpful and by this i understand the importance of the subject chemistry in drug development and this also helped me to understand the reaction that will help to give Harmony in humans
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The course on Organic Chemistry in Biology and Drug Development provides a comprehensive exploration of key concepts linking organic chemistry to the fields of biology and drug discovery. The material is presented in a clear and engaging manner, making complex topics accessible. The incorporation of real-world examples and case studies enhances the practical relevance of the content. The instructors demonstrate a strong command of the subject matter, fostering a positive learning experience. Overall, this course serves as a valuable resource for understanding the pivotal role of organic chemistry in advancing biological and pharmaceutical sciences.
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The Professor, conducted the class exceptionally well. His clear and precise explanations facilitated a thorough understanding of complex topics. The lecture structure was well thought out, making it easy for us to follow the material. The interactive nature of the classes was particularly impressive, enhancing knowledge retention. Supportive materials and practical examples further enriched the learning experience. Overall, it was an extremely educational journey that significantly enhanced my academic capabilities. I appreciate him/ Professor dedication and effectiveness, and I wholeheartedly recommend his courses. Best regards kurt
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I like the method of teaching, it is very fascinating and exciting for young chemists who are willing to specialize in the field of medicinal chemistry. A step by step approach and breakdown for learning. It's worth it...
I'm very grateful for this opportunity and delightful. I want to acknowledge the professor who has taken his time to teach meticulously -
Organic chemistry plays a crucial role in both biology and drug development. In biology, organic compounds such as carbohydrates, lipids, proteins, and nucleic acids are essential components of living organisms. Organic chemistry provides the unders…
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Very helpful course . I learnt a lot of things form this course .it will help mi lot of in my carrear . Really thankful for giving importannt information to mi. Thank you very much.as a student this course help mi a lot . Learn many things from this . And whenever information needed i again come and see this course video for learning new things . I completed all chapters of this course with very consentration
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Assem TabboushThis course of Organic Chemistry in Biology and Drug Development offered a perceptive investigation of the significant contribution organic chemistry has made to the development of biology and medicines. The course material successfully merged basic organic chemistry concepts with how they are used in medication development. The course clarified how molecular structures affect biological interactions and therapeutic efficacy through interesting lectures and real-world examples. Although demanding at times, the thorough information and the instructor's concise explanations encouraged a greater grasp of this difficult subject. Overall, the course helped students understand how organic chemistry affects healthcare in the actual world. -
It's a very nice course. I have learn very much about drug from this course. I'm very lucky to be a learner of this course Thank you so much
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Very helpful.. thanks for arranging this course .I enjoyed the content, and the data is very helpful for my current course.thank you
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Roshni QayyumI enjoy this course very much. I gain a lot of knowledge from this course this will surely help me in my future -
very nice and informative. i gained very helpful information from this course . this course is must view.
