Overview

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Embark on a comprehensive 21-hour biochemistry journey covering a wide range of topics from metabolism to protein structure and enzyme kinetics. Explore the intricacies of DNA and RNA structures, including various conformations like A, B, and Z DNA, as well as complex structures such as triple-stranded and quadruplex DNA. Delve into protein structure and folding mechanisms, examining secondary and tertiary structures, structural motifs, and important proteins like collagen and keratin. Investigate enzyme kinetics, including Michaelis-Menten plots, allosteric enzymes, and various types of enzyme inhibition. Study major metabolic pathways such as glycolysis, gluconeogenesis, the citric acid cycle, and the electron transport chain, along with their regulations and interconnections. Examine amino acid structures, central dogma processes, and specialized biochemical concepts like the Cori cycle and chemiosmotic theory. This extensive biochemistry course provides a solid foundation for understanding the molecular basis of life and cellular processes.

Syllabus

Metabolism - overview 2.
Metabolism - overview 3.
Metabolism biochemistry - locations.
Metabolism biochemistry - locations 2.
Oxidative phosphorylation.
Metabolism and metabolic pathways.
Difference between A, B and Z DNA.
Major groove and minor groove.
Propeller twist.
Sugar puckering.
Z DNA.
Triple stranded DNA.
DNA structure | Slipped DNA.
Repeat sequences in DNA.
DNA structure | Quadruplex DNA.
DNA structure | H DNA.
DNA structure | Cruciform DNA.
DNA structure | Bent DNA.
Collagen protein.
Protein structure | tertiary structure of proteins.
Protein motifs and domains | secondary structure of proteins.
Alpha helix | secondary structure | protein structure.
DNA structure | cruciform DNA, quadruplex DNA, triple stranded DNA.
Torsional angle.
Ramachandran plot.
Peptidoglycan structure and biosynthesis.
Peptide bond structure | formation and rotation of peptide bonds.
Structural motifs of protein.
Keratin protein.
Glycosaminoglycans (GAGs).
Beta sheet | beta pleated sheet | secondary protein structure.
Bacterial flagella | structure and motility.
Protein structure | Random coil structure.
RNA structure and synthesis and types.
Protein symmetry | structural symmetry.
Michaelis menten plot and equation.
Allosteric enzyme.
Double reciprocal plot for competetive inhibition.
Double reciprocal plot for mixed inhibition.
Double reciprocal plot for uncompetitive inhibition.
Double reciprocal plot.
Progress curve of simple enzyme catalyzed reaction.
Anfinsen's experiment and protein folding.
Protein folding models.
Protein folding mechanism.
Proteolysis.
Activation energy and Enzymes (Animation).
Enzyme kinetics animation.
Zymogen activation.
Enzyme substrate complex.
Isozyme.
Enzyme catalysis mechanism.
Glycolysis.
Feeder pathways of glycolysis.
Fate of pyruvate.
Galactose metabolism.
Fructose metabolism.
Breakdown of glycogen.
Glucose transport from liver to blood cell.
Glycogen metabolism.
Citric acid cycle biochemistry.
Dietary fat metabolism.
Gluconeogenesis overview.
Gluconeogenesis.
Gluconeogenesis regulation.
Role of glycogen phoisphorylase.
Gluconeogenesis pathway.
The Cori cycle.
Citric acid cycle (TCA cycle).
Regulation of citric acid cycle.
Pyruvate oxidation.
Pyruvate dehydrogenase complex.
Pentose phosphate pathway.
Pyruvate dehydrogenase complex overview.
Pyruvate dehydrogenase complex mechanism.
Regulation of pyruvate dehydrogenase complex.
Gluconeogenesis.
Metabolism big picture.
Electron transport chain animation.
Citric acid cycle explanation.
Amphibolic pathways of citric acid cycle.
Binding change mechanism of ATP synthesis.
Comparison between glycolysis and gluconeogenesis.
Coupling of ETS and ATP synthesis.
Glucose transporter 4 activity.
Regulation of hexokinase 4.
Glycogen metabolism regulation.
Malate aspertate shuttle.
Overview of glucose metabolism.
Overview of oxidative fuel metabolism.
Dolichol phosphate synthesis pathway.
Nonoxidative deamination.
Oxidative deamination.
Transamination reaction mechanism.
Tetrahydrofolate (THF).
S adenosyl methionine (SAM).
Transmethylation.
The mitochondrial electron transport chain.
The cori cycle.
Neoglucogenesis.
ATP synthesis (chemiosmotic theory).
Amino acid structures (part 2).
Amino acid structures (part 3).
Enzyme inhibition.
Enzyme catalysis.
Enzyme inhibitor (competitive inhibition).
Central dogma (replication, transcription and translation).
Amino acid structures (part 1).
Amino acid structures (part 2).
Protein splicing.