MPG Primer: Rare Variant Interpretation - 2024

Explore rare variant interpretation in this 35-minute lecture from the Medical and Population Genetics Primer series at the Broad Institute. Delivered by Wenhan Lu from the Neale and Karczewski Labs, learn about the fundamental principles of complex trait genetics, focusing on rare genetic variants and their role in human populations and disease. Gain insights into human genetic variation, genotyping techniques, DNA sequencing methods, statistical approaches, and data analysis strategies. Designed for a diverse audience including research technicians, graduate students, postdoctoral fellows, and established investigators new to the field, this accessible talk provides an in-depth introduction to key concepts in medical and population genetics. Part of a weekly series of informal discussions, this lecture contributes to a comprehensive understanding of genetics topics relevant to human health and disease research.