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Explore the fundamentals of complex trait genetics in this 39-minute video lecture from the Medical and Population Genetics Primer series at the Broad Institute. Presented by Kai Yuan, delve into topics such as human genetic variation, genotyping, DNA sequencing methods, statistics, and data analysis. Gain insights into the basic principles that relate to human populations and disease. Designed for a wide audience including research technicians, graduate students, postdoctoral fellows, and established investigators entering the field, this informal discussion offers an in-depth introduction to key concepts in medical and population genetics. Part of a weekly series, this freely available educational resource aims to enhance understanding of complex trait genetics and its applications in medical research.