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Explore the fundamentals of fine-mapping in genetics through this 50-minute lecture from the Medical and Population Genetics Primer series at the Broad Institute. Presented by Ran Cui, delve into the essential principles of complex trait genetics, focusing on fine-mapping techniques. Learn about human genetic variation, genotyping methods, DNA sequencing, statistical approaches, and data analysis strategies crucial for identifying causal variants in genetic studies. Gain insights applicable to research technicians, graduate students, postdoctoral fellows, and established investigators entering the field of medical and population genetics. Part of a comprehensive weekly discussion series, this lecture offers an accessible introduction to key concepts in genetic research and their applications in understanding human populations and diseases.