Modeling of Nucleosome Clustering in Euchromatin Resulting from Reader Protein Interactions

Explore a 25-minute talk by Joseph Wakim, PhD Candidate from the Spakowitz Group at Stanford University, on modeling nucleosome clustering in euchromatin. Delve into the fundamental chemical and physical phenomena underlying chromosomal organization and dynamics. Learn about the diverse theoretical and computational methods employed, including analytical theory of semiflexible polymers, polymer field theory, and Brownian dynamics simulation. Gain insights into the multidisciplinary approach used to capture phenomena across various length and time scales. Understand how this research contributes to the broader themes of the Spakowitz lab, which include protein self-assembly, polymer membranes, and charge transport in conducting polymers. Discover the implications of this work for physical genomics and cancer research, supported by the Center for Physical Genomics and Engineering at Northwestern University and the Cancer and Physical Sciences Program at the Robert H. Lurie Comprehensive Cancer Center.