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Explore a physicist's perspective on genome modeling in this hour-long lecture from the 3rd ICTP-SAIFR Symposium on Current Topics in Molecular Biophysics. Delve into the interdisciplinary approach of applying physics principles to understand genomic structures and functions. Learn how José Onuchic from Rice University bridges the gap between physics and biology, offering unique insights into the complexities of genetic material. Gain a deeper understanding of how physical models can illuminate genomic processes and potentially revolutionize our comprehension of life at the molecular level.