Overview
Syllabus
Intro
Immunotherapy has become an important clinical tool for a number of malignancies...
Competition of cancer cells and immune cells for nutrients can keep the immune system from killing tumors
Interstitial fluid profiling allows us to measure nutrient stress in the PDAC TME...
and develop model systems to study how nutrient stress impacts PDAC biology
TIFM exposure blocks EXPANSION and FUNCTION
Arginine depletion in TIFM inhibits T cell EXPANSION but not FUNCTION
Reducing tumoral phosphoethanolamine levels improves adoptive T cell therapy
Taught by
Labroots