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Metabolic Barriers to Tumor Immunity in Pancreatic Cancer
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- 1 Intro
- 2 Immunotherapy has become an important clinical tool for a number of malignancies...
- 3 Competition of cancer cells and immune cells for nutrients can keep the immune system from killing tumors
- 4 Interstitial fluid profiling allows us to measure nutrient stress in the PDAC TME...
- 5 and develop model systems to study how nutrient stress impacts PDAC biology
- 6 TIFM exposure blocks EXPANSION and FUNCTION
- 7 Arginine depletion in TIFM inhibits T cell EXPANSION but not FUNCTION
- 8 Reducing tumoral phosphoethanolamine levels improves adoptive T cell therapy
