Metabolic Barriers to Tumor Immunity in Pancreatic Cancer

Metabolic Barriers to Tumor Immunity in Pancreatic Cancer

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Intro

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1 of 8

Intro

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Metabolic Barriers to Tumor Immunity in Pancreatic Cancer

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  1. 1 Intro
  2. 2 Immunotherapy has become an important clinical tool for a number of malignancies...
  3. 3 Competition of cancer cells and immune cells for nutrients can keep the immune system from killing tumors
  4. 4 Interstitial fluid profiling allows us to measure nutrient stress in the PDAC TME...
  5. 5 and develop model systems to study how nutrient stress impacts PDAC biology
  6. 6 TIFM exposure blocks EXPANSION and FUNCTION
  7. 7 Arginine depletion in TIFM inhibits T cell EXPANSION but not FUNCTION
  8. 8 Reducing tumoral phosphoethanolamine levels improves adoptive T cell therapy

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