Abnormal Mechanics in Brain Tumors: Implications for Immunotherapy

Explore the implications of abnormal mechanics in brain tumors for immunotherapy in this 56-minute seminar by Dr. Meenal Datta. Delve into the challenges faced by glioblastoma patients and the potential role of the tumor microenvironment in treatment resistance. Learn about "solid stress," a mechanical force that compresses blood vessels, induces hypoxia and immunosuppression, and hinders immunotherapy efficacy. Discover findings from patient and mouse model studies demonstrating how solid stress can be measured and applied in vivo, damages surrounding healthy brain tissue, and can be targeted to restore neurological function and overcome immunotherapy resistance. Gain insights into mechanical models, methods for measuring solid stress, and strategies to target it, including the use of Losartan to enhance therapeutic outcomes and improve immune checkpoint blockade efficacy. Understand the complex interplay between tumor mechanics, the immune microenvironment, and treatment response in glioblastoma.