Dive into a comprehensive 3-hour lecture on jaundice, exploring its types, causes, symptoms, and treatments. Learn the distinctions between jaundice, hyperbilirubinemia, icterus, and cholestasis. Examine hemoglobin structure, hemosiderin formation, and bilirubin metabolism. Understand the pathophysiology of hyperbilirubinemia, including unconjugated and conjugated forms. Explore various clinical conditions, from newborn jaundice to inherited disorders and hepatitis. Investigate intrahepatic and extrahepatic cholestasis, their causes, and diagnostic approaches. Conclude with clinical scenarios covering obstructive jaundice, extravascular hemolysis, hepatitis, and pancreatic carcinoma, providing a thorough understanding of this complex medical condition.
Overview
Syllabus
Definition of jaundice and how it is different from hyperbilirubinemia, icterus, and cholestasis?
Structure of hemoglobin and its types .
Formation of hemosiderin and the difference between hemosiderosis and hemochromatosis.
Binding of unconjugated bilirubin with bilirubin binding protein and its clinical correlation.
Conjugation of unconjugated bilirubin inside the liver and its clinical correlates.
Transport of conjugated bilirubin through the biliary canalicular system into GIT.
Modification of conjugated bilirubin in GIT.
Reabsorption of Urobilinogen into portal circulation its fates and clinical correlations.
A detailed explanation of the pathophysiology of hyperbilirubinemia.
Clinical conditions which cause unconjugated hyperbilirubinemia.
Causes of physiologic jaundice of newborn.
What is breast milk jaundice?
Inherited disorders due to deficiency of glucuronyl transferase.
Detailed explanation on impaired conjugation of bilirubin occurred by hepatitis.
Detailed explanation on Intrahepatic and extrahepatic cholestasis.
Causes of intrahepatic biliary obstruction.
Causes of pregnancy related cholestasis.
Causes of extrahepatic biliary obstruction.
Detailed explanation on diagnosis of jaundice under different conditions.
How the diagnosis of cholestasis is made and the concept of xanthoma and xanthelasma?
A rapid review of obstructive jaundice.
Detailed explanation on intra hepatic and extra hepatic cholestasis.
Clinical scenario of Obstructive jaundice.
Clinical scenario of Extravascular hemolysis.
Clinical scenario of Acute and chronic hepatitis.
Clinical scenario of Carcinoma of the head of pancreas.
Taught by
Dr. Najeeb Lectures
