Dive into a comprehensive 3-hour lecture on jaundice, its types, symptoms, and treatments. Explore the intricacies of bilirubin metabolism, differentiate between hyperbilirubinemia, icterus, and cholestasis, and understand hemoglobin structure and types. Learn about hemosiderin formation, bilirubin binding and conjugation processes, and their clinical correlations. Examine the pathophysiology of hyperbilirubinemia, causes of unconjugated hyperbilirubinemia, and various types of jaundice including newborn and breast milk jaundice. Investigate inherited disorders, hepatitis-related bilirubin conjugation issues, and both intrahepatic and extrahepatic cholestasis. Analyze diagnostic approaches for different jaundice conditions, including obstructive jaundice, and explore clinical scenarios involving extravascular hemolysis, acute and chronic hepatitis, and pancreatic carcinoma. Gain valuable insights into this complex medical topic through detailed explanations and real-world clinical applications.
Overview
Syllabus
Definition of jaundice and how it is different from hyperbilirubinemia, icterus, and cholestasis?
Structure of hemoglobin and its types .
Formation of hemosiderin and the difference between hemosiderosis and hemochromatosis.
Binding of unconjugated bilirubin with bilirubin binding protein and its clinical correlation.
Conjugation of unconjugated bilirubin inside the liver and its clinical correlates.
Transport of conjugated bilirubin through the biliary canalicular system into GIT.
Modification of conjugated bilirubin in GIT.
Reabsorption of Urobilinogen into portal circulation its fates and clinical correlations.
A detailed explanation of the pathophysiology of hyperbilirubinemia.
Clinical conditions which cause unconjugated hyperbilirubinemia.
Causes of physiologic jaundice of newborn.
What is breast milk jaundice?
Inherited disorders due to deficiency of glucuronyl transferase.
Detailed explanation on impaired conjugation of bilirubin occurred by hepatitis.
Detailed explanation on Intrahepatic and extrahepatic cholestasis.
Causes of intrahepatic biliary obstruction.
Causes of pregnancy related cholestasis.
Causes of extrahepatic biliary obstruction.
Detailed explanation on diagnosis of jaundice under different conditions.
How the diagnosis of cholestasis is made and the concept of xanthoma and xanthelasma?
A rapid review of obstructive jaundice.
Detailed explanation on intra hepatic and extra hepatic cholestasis.
Clinical scenario of Obstructive jaundice.
Clinical scenario of Extravascular hemolysis.
Clinical scenario of Acute and chronic hepatitis.
Clinical scenario of Carcinoma of the head of pancreas.
Taught by
Dr. Najeeb Lectures
