Fossils of Ancient Chromosomes

Explore the groundbreaking research on ancient genome reconstruction in this 53-minute lecture by Dr. Erez Lieberman Aiden, Associate Professor at Baylor College of Medicine. Delve into the innovative Hi-C protocol for mapping long-range genomic interactions and its applications in creating 3D maps of the human genome. Learn about the development of in situ and intact Hi-C techniques, leading to kilobase resolution contact maps and chromatin loop annotations. Discover how these methods have revolutionized genome assembly, enabling the creation of high-quality mammalian genomes from short Illumina reads for under $1,000. Uncover the exciting potential of combining Hi-C with long reads for extraordinary genome quality and its role in assembling genomes of ancient species like the woolly mammoth. Gain insights into Dr. Aiden's award-winning research and its impact on understanding DNA structure and genomics.