Alterations in Spatial Genome Compartmentalization Associated with Constriction and Expansion

Explore the fascinating world of 3D genome structure and its response to physical stresses in this 52-minute seminar by Dr. Rachel Patton McCord. Delve into the latest research on how chromosome folding inside the cell nucleus affects fundamental biological processes and learn about the molecular factors that build genome structure. Discover how the 3D genome structure responds to perturbations such as physical forces and nuclear shape changes, and understand the implications of disruptions in genome structure for diseases like cancer and premature aging. Examine the innovative techniques used to probe human 3D genome architecture, including microscopy, computational analysis, and chromosome conformation capture (Hi-C). Gain insights into the striking differences in chromosome spatial compartmentalization observed in melanoma cells after constricted migration, and explore the potential causes and effects of these changes. Investigate the shared features of chromosome structure shifts in melanoma and breast cancer cells, and learn about the preservation of chromosome contacts during nuclear expansion. This seminar, sponsored by the Center for Physical Genomics and Engineering at Northwestern University and the Robert H. Lurie Comprehensive Cancer Center, offers a comprehensive look at the robustness of 3D genome structure and its role in gene regulation and nuclear physical properties.