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YouTube

Coronary Artery Disease - From Genetics to Drug Development

University of Ottawa Heart Institute via YouTube

Overview

Learn about coronary artery disease through a comprehensive research conference presentation that explores genetic studies, risk factors, and drug development. Delve into advanced topics including Affymetrix chips, polygenic risk variance, noncoding regions, and computational approaches in cardiovascular genetics. Explore the relationship between genetics and coronary disease, examining microRNAs, Mendelian evangelization, cholesterol, LDL, and functional genomics. Discover cutting-edge developments in target discovery, antisense technology, and security randomization while understanding how genetic risk scores and risk alleles contribute to disease management. Presented by Dr. Ruth McPherson, Director of the Ruddy Canadian Cardiovascular Genetics Centre and Professor at the University of Ottawa, this hour-long talk provides valuable insights into the intersection of genetics and cardiovascular medicine.

Syllabus

Intro
Genetic studies
What are genetics
Affymetrix chips
Polygen
Risk variance
Risk factors
New biology
Complex disease
Source of study
Noncoding regions
G1 studies
Computational approaches
Pathway analysis
Other studies
MicroRNAs
Mendelian evangelization
MRAS
Cholesterol
LDL
Functional genomics
Target discovery
Reducing triglycerides
Homozygous FH
Antisense
Security randomization
Genetics and coronary disease
Genetic risk score
Risk alleles
Polygenic risk
Thank you
Question

Taught by

University of Ottawa Heart Institute

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