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Explore the genetics of coronary artery disease (CAD) and its potential for vaccine development in this comprehensive lecture. Gain insights into DNA risk variants predisposing to CAD, understand the evidence challenging the protective role of HDL-C against CAD, and learn about the confirmed links between short stature, blood groups A and B, and increased CAD risk. Discover how genetic information can be utilized as a polygenic risk factor to stratify CAD risk and identify high-risk individuals for primary prevention. Delivered by Dr. Robert Roberts, Executive Director of the Heart and Vascular Institute at Dignity Health St. Joseph's Hospital and Medical Center, this DeBakey Heart & Vascular Center Grand Rounds presentation offers a comprehensive overview of the latest advancements in CAD genetics and its implications for future preventive strategies.