RNA Methylation in Chromatin Regulation

Explore a 33-minute lecture on RNA methylation in chromatin regulation delivered by Chuan He, the John T. Wilson Distinguished Service Professor at the University of Chicago. Delve into He's groundbreaking research spanning chemical biology, RNA biology, epigenetics, biochemistry, and genomics. Learn about the discovery of reversible RNA methylation as a new mechanism of gene expression regulation and the characterization of the RNA m6A methyltransferase complex. Understand the significance of m6A methylation on chromatin-associated regulatory RNAs (carRNAs) and its role in regulating chromatin state and global transcription. Gain insights into the development of enabling technologies for studying RNA and DNA modifications. This talk, presented at the 2023 Symposium on Physical Genomics at Northwestern University, offers a comprehensive look at cutting-edge research in the field of RNA biology and its implications for understanding gene regulation and chromatin dynamics.