ATP-Dependent Remodeling of Hexasomes, Nucleosomes and Chromatin Condensates

Explore the fascinating world of ATP-dependent chromatin remodeling complexes and their critical role in regulating DNA access in this 58-minute lecture by Dr. Geeta Narlikar. Delve into the unique properties of the INO80 complex, which preferentially mobilizes subnucleosomal particles called hexasomes. Discover novel mechanistic adaptations that explain INO80's preference for hexasomes over nucleosomes. Examine how chromatin remodeling complexes impact higher-order chromatin organization, including their effect on phase-separated chromatin condensates. Gain insights into new biologically relevant activities of chromatin remodeling enzymes and their implications for genome packaging and organization. Learn about Dr. Narlikar's groundbreaking research in epigenetic regulation and genome organization, including her laboratory's pioneering application of sophisticated biophysical approaches to study macromolecules regulating genome organization. Understand how these discoveries are changing textbook descriptions of genome packaging and opening new avenues for tackling diseases caused by defects in genome organization.