Near-atomistic Modeling of Chromatin - Insights into Structure and Dynamics

Explore a seminar on near-atomistic modeling of chromatin presented by Dr. Xingcheng Lin from MIT at the Lennard-Jones Centre discussion group. Delve into the complex world of three-dimensional chromatin organization and its role in gene expression and epigenetic regulation. Examine the ongoing debate surrounding chromatin fibril structure and its response to environmental changes. Investigate the solid and liquid properties of chromatin under various experimental conditions. Learn how recent computational advances and a near-atomistic chromatin model are used to study structural details of large chromatin systems. Discover insights into tetranucleosome folding pathways, force-extension relationships in dodecameric nucleosomal arrays, and the formation of trinucleosome and tetranucleosome clutches under tension. Explore the concept of interdigitated chromatin configurations and their potential role in sol-gel transitions. Gain an understanding of how this integrated approach reconciles chromatin conformations in various environments and provides mechanistic insights into genome organization. The 22-minute seminar, held on February 28, 2022, offers a comprehensive look at cutting-edge research in chromatin modeling and its implications for understanding fundamental biological processes.