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Tsinghua University

Introduction to Cancer Biology

Tsinghua University via XuetangX

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Overview

Learn about cancer biology through a comprehensive course covering both traditional Chinese medicine and Western medicine approaches to oncology. Explore fundamental concepts including tumor regulation, viral oncology, diagnostic methods, and cell signaling pathways. Examine the multistep process of tumorigenesis, genomic integrity, and cancer stem cells while studying common clinical cancers like colorectal, breast, and lung cancer. Master the roles of oncogenes and tumor-suppressor genes, understand tumor growth patterns, and investigate the relationship between tumors and the immune system. Discover modern treatment approaches including minimally invasive medicine and personalized therapy strategies. Gain a thorough foundation in both the historical context and cutting-edge developments in cancer biology through detailed examination of molecular mechanisms, diagnostic techniques, and therapeutic interventions.

Syllabus

  • Chapter 1: Introduction to oncology
    • 1. History of TCM oncology
    • 2. History of Western Medicine oncology——Part of basic medicine
    • 3. History of Western Medicine oncology——Part of clinical medicine
  • Chapter 2: Regulation of tumorigenesis and apoptosis
    • 1. Discovery and function of p53
    • 2. Regulation of apoptosis signal
  • Chapter 3：Viruses and tumors
    • 1. Oncogenic virus and cell transformation
    • 2. Pathogenesis of oncogenic virus
  • Chapter 4: Tumor diagnosis
    • 1. Pathological diagnosis of tumor 1-- definition, history, and terminology of tumor pathology
    • 2. Pathological diagnosis of tumor 2- diagnosis basis and overview of tumor
    • 3. Pathological diagnosis of tumor 3- Common techniques for pathological diagnosis
    • 4. Molecular diagnosis of tumor markers
  • Chapter 5: Cell signaling pathway and tumors
    • 1. Overview of tumor cell signaling pathways
    • 2. NF-kB signal pathway
    • 3. JAK-STAT signal pathway
    • 4. Wnt signal pathway
    • 5. TGF-β signal pathway
    • 6. Nuclear receptor signal pathway
  • Chapter 6: Multistep tumorigenesis and genomic integrity
    • 1. Multistep mechanism of tumorigenesis
    • 2. Tumor stem cells
    • 3. Non-genetic mutations and tumor
  • Chapter 7: Clinical common tumor
    • 1. Colorectal cancer
    • 2. Breast cancer
    • 3. Lung cancer
  • Chapter 8: Oncogenes and tumor-suppressor genes
    • 1. Oncogenes
    • 2. Tumor-suppressor genes
  • Chapter 9: Cell proliferation and tumor growth
    • 1. Patterns and Dynamics of tumor growth
    • 2. Cell cycle and tumors
    • 3. Tumor angiogenesis
  • Chapter 10: Tumor and immunity
    • 1. Tumor antigens
    • 2. Immune effect mechanism against tumor
    • 3. Immune escape mechanism of tumor
  • Chapter 11: Tumor and minimally invasive medicine
    • 1. Overview of minimally invasive medicine
    • 2. Application of minimally invasive medicine for tumor therapy
  • Chapter 12: Personalized medicine for tumor treatments
    • 1. Overview of Personalized medicine
    • 2. Application of personalized medicine for tumor therapy

Taught by

Daliang Wang

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