Overview
Syllabus
Intro
Research Area 1: Context-dependent regulation of survival signaling in cancer
Research Area 2: Functional tumor evolution
Vulnerabilities arising during tumor evolution
Mapping the beneficial and detrimental effects of selinexor
AKT activation is a beneficial effect of selinexor
Selinexor-induced P2RY2 upregulation is necessary and sufficient for AKT activation
P2RY2-driven AKT activation requires p110g, p101, and Ras
Antagonistic Pleiotropy: Genes that couple sensitivity and resistance
Systematic analysis of AP
A PRC2/NSD/MYC AP axis
PRC2/MYC dysregulation drives evolved BRD4i resistance
MYC drives BIM-dependent apoptotic priming and BCL-2 inhibitor sensitivity
Taught by
Labroots