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Indian Institute of Technology Bombay

NMR spectroscopy for Chemists and Biologists

Indian Institute of Technology Bombay and NPTEL via Swayam

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Overview

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This course will start with Basic principles of NMR, walk through the analysis of spectra and demonstrate the application of multidimensional NMR spectroscopy in Chemistry and structural Biology.
INTENDED AUDIENCE: M. Sc./ PhD and Scientists working in Pharma and Biophrma IndustriesPREREQUISITES: Under graduate level understanding of Physics and Mathematics
INDUSTRY SUPPORT: Biocon, Wockhardt, Aurobindo Biopharma etc

Syllabus

COURSE LAYOUT

Week 1 :
  • Nuclear Spin and Magnetic Moments
  • Nuclear Spins in a Magnetic Field Spin
  • Lattice Relaxation Spin temperature Resonance
  • Absorption of Energyand The NMR Experiment Resonance
  • Absorption of Energy and The NMR Experiment Kinetics of Resonance Absorption
Week 2 :
  • Selection Rules and Line widths
  • Bloch equations
  • More about relaxation
  • More about relaxation Sensitivity
Week 3 :
  • Instruction to operator Algebra
  • Chemical Shift
  • Anisotropy ofchemical shifts Learning spectral simulation
Week 4 :
  • Factors Influencing Isotropic Chemical shifts: Spin Spin Coupling
  • Analysis of NMR spectra of molecules
  • Learning spectral simulation
Week 5 :
  • Dynamic Effects in the NMR spectra : Two site exchange
  • Collapse of spin multiplets
  • Conformational Averaging of J- values
  • Analysis of NMR spectra of molecules with J Values
Week 6 :
  • Principles of Fourier transform
  • NMR Theorems on Fourier transforms
  • Practical aspects of recording FTNMR spectra
  • Free Induction Decay (FID) and the spectrum
  • Pulse repetition rate
  • Folding of signals
  • Acquisition time and the resolution
  • Data processing in FT
  • NMR Learning of Data processing
Week 7 :
  • Dynamic range in FTNMR and solvent suppression
  • The Nuclear Overhauser Effect - Experimental Schemes,Advanced Treatment
  • Steady state NOE and Transient NOE
Week 8 :
  • Spin Echo Uncoupled spins
  • Spin Echo Coupled spins
  • Spin-lattice relaxation
  • Spin-spin relaxation
  • Polarization transfer SPT and INEPT spectralsimulation
Week 9 :
  • Density matrix, Elements of Density Matrix, Time evolution of density operator
  • Time evolution of density operator
  • Product operatorformalism
Week 10 :
  • Segmentation of the time axis
  • Two dimensional NMR 2D
  • Fourier Transformation in NMR
  • Peak shapes in 2D spectrum
  • Quadrature detection in two-dimensional NMR
Week 11 :
  • 2D- resolution/ separation experiments
  • Two-dimensional correlation experiments COSY,TDQ-COSY etc TOCSY
Week 12 :
  • 2D NOESY, 2D ROESY, Heteronuclear COSY,
  • The HETCOR pulse sequence HSQC


Taught by

Prof. Ashutosh Kumar & Prof. R. V. Hosur

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