Complexity Dynamics of Atopic Dermatitis System

Explore the complexity dynamics of atopic dermatitis (AD) in this 30-minute conference talk by Younghae Do from PCS Institute for Basic Science. Delve into an in silico AD model based on disease pathogenesis mechanisms, described by a nonsmooth system with three switches. Discover a new oscillating behavior called Serious Oscillation, which aids in classifying AD attractors similar to clinical symptoms used in the SCORAD index. Examine the existence and stability of attractors on the parameter space for barrier permeability and immune responses, revealing various types of bi- and multistability. Gain insights into how multistability contributes to AD's complexity and its potential applications in developing new therapeutic strategies. Observe a unique bifurcation phenomenon in nonsmooth dynamical systems, enhancing understanding of AD's intricate nature.