Comparative Analysis of Relative Fragmentation Stabilities in Polymorphic Amyloid Fibrils

Explore a comprehensive lecture on the comparative analysis of fragmentation stabilities in polymorphic amyloid fibrils. Delve into the crucial role of fibril fragmentation in neurodegenerative disorders like Alzheimer's and Parkinson's diseases. Learn about a novel analytical approach for comparing the relative stabilities of different amyloid fibril types towards fragmentation. Discover how controlled sonication can be used as a mechanical perturbation method for rapid assessment of fragmentation stabilities in polymorphic amyloid fibril structures. Gain insights into the diverse nature of fragmentation stabilities among different amyloid fibril polymorph structures and understand the potential applications of this approach in comparing relative stabilities under various biological conditions. The lecture covers topics such as the assembly process, division process, size distribution modeling, atomic force microscopy, filament analysis, and the challenges in studying amyloid fibril polymorphism.