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Explore the powerful capabilities of Istio in managing Kubernetes clusters and addressing challenges in distributed systems. Dive into topics such as circuit-breaking, retries, timeouts, blue-green deployments, A/B testing, and pool-ejections. Learn how Istio can replace the Netflix stack and dedicated frameworks in microservices environments. Discover new development paradigms introduced by Istio for deploying and operating resilient applications. Gain insights into Istio's architecture, internal components, and latest features. Understand how to customize underlying elements like the Envoy Proxy and implement Istio at scale across containers and VMs. This 40-minute conference talk from Devoxx provides a comprehensive overview of Istio as an essential tool for enhancing Kubernetes cluster management and solving modern distributed system challenges.