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Explore how privacy-preserving computation and secure multiparty computation can enhance nuclear safeguards without compromising state secrets in this 20-minute conference talk from USENIX Enigma 2021. Delve into the potential of garbled circuits for detecting anomalies in nuclear safeguards-relevant time series data, allowing international inspectors and nation-states to perform joint calculations while maintaining input confidentiality. Learn about the challenges faced in implementing modern data analytics in nuclear safeguards, and discover how this innovative approach can bridge the gap between regulatory compliance and data privacy concerns in nuclear material protection.