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Explore cutting-edge ultraresolution imaging techniques for deep tissue visualization and a novel information-based theoretical resolution limit in this invited talk by Dr. Fang Huang at the 2024 Symposium on Physical Genomics. Delve into the latest advancements in optical imaging technologies aimed at defining cellular structures and functions with molecular precision in live cells and tissues. Gain insights from the Reilly Associate Professor of Biomedical Engineering at Purdue University, whose research collaborates with cell biologists, neuroscientists, and chemists to address biological questions in cytokinesis, epigenetics, neural circuits, and cell motility. Learn about the potential applications of these imaging techniques in revealing disease mechanisms for Alzheimer's, autism, and cancer. Discover how interdisciplinary research funded by NIH, DARPA, and the BRAIN Initiative is pushing the boundaries of physical genomics and engineering.