Explore a 58-minute seminar on ancestry-driven drug discovery and its impact on health disparities, presented by Dr. K. Sean Kimbro from North Carolina Central University. Delve into the molecular characterization of hormonal cancers disproportionately affecting individuals of African ancestry and other ethnic groups. Gain insights into how research on ancestry-related host immunity contributes to understanding health disparities biology. Learn about migration patterns, unnatural selection, and the concept of American Descendants of Enslaved Africans (ADEA). Examine protective innate immune variants in racial/ethnic disparities of breast and prostate cancer, and discover the potential of designing drugs from an ancestral perspective. Investigate the misclassification of commonly used cancer cell lines and the importance of targeting IL-4 and IL-13 receptors for cancer therapy. Conclude with a Q&A session addressing key topics in this cutting-edge field of genomics and personalized medicine.
The Biology of Health Disparities: Ancestry-Driven Drug Discovery - K. Sean Kimbro
National Human Genome Research Institute via YouTube
Overview
Syllabus
- Introduction Julie Segre
- Start of Presentation K. Sean Kimbro
- About North Carolina Central University
- Kimbro Lab
- Migration and Forced Migration
- Unnatural Selection
- American Descendants of Enslaved Africans ADEA
- Protective Innate Immune Variants in Racial/Ethnic Disparities of Breast and Prostate Cancer
- Signatures of Environmental Genetic Adaptation Pinpoint Pathogens as the Main Selective Through Human Evolution
- IRA and TLR3 Sequence Variants May Alter Breast Cancer Risk Among African American Women
- Research Papers
- What would it look like to design drugs from a different perspective?
- 2020 Drug Trials Snapshot Summary Report
- Share of world population by major regions
- Race-based Drugs BIDIL
- Ancestral-Driven Drug Discovery
- Ancestral characterization of 1018 cell lines highlights disparities and reveals gene expression and mutual differences
- Genetic Ancestry Analysis Reveals Misclassification of Commonly Used Cancer Cell Lines
- New Approach: Addressing the Biology of Health Disparities by Targeting Geographical
- Molecular Profiling and Ancestral Proportions Triple Negative Breast Cancer TNBC Cell Lines
- The neuroendocrine mechanisms of chronic stress
- IC50s with Norepinephrine
- Increased circulating cytokine levels in African American women with obesity and elevated HbA1c
- Importance of Targeting IL-4 and IL-13 receptors for cancer therapy
- IL4/IL4R-activated signaling pathways that promote growth phenotypes
- Linear Map of IL4R
- IL4R Variants of Interest
- Acknowledgements
- Q&A Session
- Prevalence of selected innate immunity sequence variants in TNBC cell lines
- AlphaFold outputs for IL4R wt and variants
- Goal
- Things to think about
Taught by
National Human Genome Research Institute
