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- Introduction Julie Segre
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The Biology of Health Disparities: Ancestry-Driven Drug Discovery - K. Sean Kimbro
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- 1 - Introduction Julie Segre
- 2 - Start of Presentation K. Sean Kimbro
- 3 - About North Carolina Central University
- 4 - Kimbro Lab
- 5 - Migration and Forced Migration
- 6 - Unnatural Selection
- 7 - American Descendants of Enslaved Africans ADEA
- 8 - Protective Innate Immune Variants in Racial/Ethnic Disparities of Breast and Prostate Cancer
- 9 - Signatures of Environmental Genetic Adaptation Pinpoint Pathogens as the Main Selective Through Human Evolution
- 10 - IRA and TLR3 Sequence Variants May Alter Breast Cancer Risk Among African American Women
- 11 - Research Papers
- 12 - What would it look like to design drugs from a different perspective?
- 13 - 2020 Drug Trials Snapshot Summary Report
- 14 - Share of world population by major regions
- 15 - Race-based Drugs BIDIL
- 16 - Ancestral-Driven Drug Discovery
- 17 - Ancestral characterization of 1018 cell lines highlights disparities and reveals gene expression and mutual differences
- 18 - Genetic Ancestry Analysis Reveals Misclassification of Commonly Used Cancer Cell Lines
- 19 - New Approach: Addressing the Biology of Health Disparities by Targeting Geographical
- 20 - Molecular Profiling and Ancestral Proportions Triple Negative Breast Cancer TNBC Cell Lines
- 21 - The neuroendocrine mechanisms of chronic stress
- 22 - IC50s with Norepinephrine
- 23 - Increased circulating cytokine levels in African American women with obesity and elevated HbA1c
- 24 - Importance of Targeting IL-4 and IL-13 receptors for cancer therapy
- 25 - IL4/IL4R-activated signaling pathways that promote growth phenotypes
- 26 - Linear Map of IL4R
- 27 - IL4R Variants of Interest
- 28 - Acknowledgements
- 29 - Q&A Session
- 30 - Prevalence of selected innate immunity sequence variants in TNBC cell lines
- 31 - AlphaFold outputs for IL4R wt and variants
- 32 - Goal
- 33 - Things to think about
