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Explore strategies and Python tools for creating semantically interoperable REST APIs in this 45-minute conference talk from EuroPython 2022. Delve into contract-first API development using OpenAPI 3, ontologies, and controlled vocabularies like those published by the European Union. Learn about the rdflib and pyld Python libraries for processing JSON-LD and RDF files, and discover the benefits of using centralized catalogs such as schema.org. Gain insights into enhancing API design and data modeling without prior knowledge of semantics and ontologies, but with practical experience in OpenAPI, JSON schema, and general API design principles.