Selectins and Adhesion Molecules - Structure, Types and Clinical Applications

Learn about the structure, types, and functions of selectins - a family of cell adhesion molecules - in this comprehensive medical lecture. Explore the three main types (E-selectin, L-selectin, and P-selectin), their unique structural components including the calcium-dependent lectin domain, EGF-like domain, and consensus repeat units, and their distribution across different cell types. Understand how these single-chain transmembrane glycoproteins function in cell adhesion through sugar binding, their varying tissue distributions, and their roles in different pathophysiological processes. Discover the sequence homology between different selectins, the conservation of their lectin domains, and how their distinct cytoplasmic and transmembrane domains determine their cellular targeting and function.