Explore a comprehensive video lecture on receptors and drugs, focusing on epinephrine, norepinephrine, and albuterol. Delve into the components of G-Protein Coupled Receptors, ligand binding domains, and factors affecting ligand-receptor interactions. Understand the concepts of agonists and antagonists, structure-activity relationships, and the differences between catecholamines and non-catecholamines. Learn about the importance of alpha and beta carbons and amine groups in sympathomimetics, as well as the receptor specificity of various drugs. Gain valuable insights into pharmacology and drug mechanisms through this in-depth, 73-minute educational presentation.
Overview
Syllabus
00:00:00- Intro to the lecture
00:00:24- Components of G-Protein Coupled Receptors
00:03:45- Ligand Binding Domain
00:04:40- Factors affecting interaction between the Ligand and Ligand binding domain
- Concept of Agonist and Antagonist
00:11:04- Structure activity relationship
00:13:40- Catecholamines introduction
00:21:03- Catecholamines vs non-Catecholamines
00:35:56- How Non-Catecholamines act as mixed-action agonists
00:40:24- Importance of Alpha, Beta carbons and amine groups in sympathomimetics
00:56:00- Receptor specificity of Norepinephrine, Epinephrine, Isoproterenol and Salbutamol Albuterol
01:10:24- Review of this lecture
Taught by
Dr. Najeeb Lectures
